![]() Amyloid accumulation is seen in almost all adults over 40 with Down syndrome. The build-up of amyloid protein in the brain disrupts the way brain cells communicate to each other. Chromosome 21 plays a key role in the relationship between Down syndrome and Alzheimer’s disease as it carries a gene that produces one of the key proteins, amyloid protein, involved with changes in the brain associated with Alzheimer’s.Scientists think the increased risk of Alzheimer’s disease among people with Down syndrome results from the extra genes present as well as other health issues such as congenital heart defects. ![]() What Causes the Increased Risk for Alzheimer's Disease Among People With Down Syndrome? 3 Some estimates put the worldwide population of people with Down syndrome at more than 6 million. Estimates for the number of people with Down syndrome in the United States have grown from nearly 50,000 in 1950 to 206,366 in 2010. 21 as World Alzheimer’s Day and recognition that people with Down syndrome have an increased risk of developing Alzheimer’s, CDC and its partners are focused on sharing information and resources to help support people with Down syndrome, their families, caregivers, health care providers, and public health professionals. About 50% of people with Down syndrome in their 60s have Alzheimer’s disease. According to the National Down Syndrome Society, about 30% of people with Down Syndrome who are in their 50s have Alzheimer’s disease. ![]() 1Īs with all adults, advancing age increases the chances a person with Down syndrome will develop Alzheimer’s disease. In 2020, life expectancy in the United States was age 60, representing an increase of 35 years when compared to 1983. ![]() Adults with Down syndrome are living longer lives with increased well-being. ![]()
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